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Challenges in Sepsis Diagnosis and Care
Sepsis is often overlooked or recognized too late. The later sepsis is recognized, the more deadly it will become [7].
The mortality rates associated with sepsis remains higher than prostate cancer, breast cancer, and HIV/AIDS combined. This is despite strict guidelines for the implementation of early and effective therapies which improve the chance of survival [6,8].
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CRP
CRP is a well-established biomarker of infection, inflammation, and is widely used in clinics and emergency departments.
PCT
Rapid, accurate PCT testing at the point of care is a vital aid to diagnosing sepsis.
Lactate
Lactate levels are typically elevated in patients with sepsis and septic shock.
References
1. Singer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016
2. Rudd et al. Global, regional, and national sepsis incidence and mortality, 1990 -2017: analysis for the Global Burden of Disease Study. The Lancet Volume 395, Issue 10219, 18 -24 January 2020; 200-211.
3. Rhee C, Jones TM, Hamad Y, Pande A, Varon J, O’Brien C, Anderson DJ, et al. Prevalence, Underlying Causes, and Preventability of Sepsis-Associated Mortality in US Acute Care Hospitals. JAMA Network Open 2019; 2,2.
4. Mostel Z, Perl A, Marck M, Mehdi SF, Lowell B, Bathija S, et al. Post-sepsis syndrome – an evolving entity that afflicts survivors of sepsis. Molecular Medicine 2020) 26,6.
5. What Is Sepsis? — World Sepsis Day - September 13. Assessed November 2022
6. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016; 315,8.
7. Seymour CW, Gesten F, Prescott HC, Friedrich ME, Iwashyna TJ, Phillips GS, et al. Time to Treatment and Mortality during Mandated Emergency Care for Sepsis. n engl j med 2017; 376, 23.
8. Vincent JL. Increasing awareness of sepsis: World Sepsis Day. Crit Care 2012
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